Stable duplex-linked antisense targeting miR-148a inhibits breast cancer cell proliferation

Abstract MicroRNAs (miRNAs) regulate cancer cell proliferation by binding directly to the untranslated regions of messenger RNA (mRNA). MicroRNA-148a (miR-148a) is expressed at low levels in breast cancer (BC). However, little attention has been paid to the sequestration of miR-148a. Here, we perfor...

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Bibliographic Details
Main Authors: Sho Okumura, Yu Hirano, Yasuo Komatsu
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-90972-3