Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils

Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils

Semen harbors amyloid fibrils formed by proteolytic fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120) and semenogelins (SEM1 and SEM2) that potently enhance HIV infectivity. Amyloid but not soluble forms of these peptides enhance HIV infection. Thus, agents that remodel these amyloi...

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Bibliographic Details
Main Authors: Laura M. Castellano, Rebecca M. Hammond, Veronica M. Holmes, Drew Weissman, James Shorter
Format: Article
Language:English
Published: The Company of Biologists 2015-09-01
Series:Biology Open
Subjects:
EGCG
SEVI
PAP85-120
SEM1
SEM2
HIV infectivity
Online Access:http://bio.biologists.org/content/4/9/1206

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