Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity

When a T cell infiltrates a tumor, it is subjected to a variety of immunosuppressive and regulatory signals in the microenvironment. However, it is becoming increasingly clear that due to the proliferative and energetically-deregulated nature of tumor cells, T cells also operate at a metabolic disad...

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Bibliographic Details
Main Authors: Nicole E. Scharping, Greg M. Delgoffe
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Vaccines
Subjects:
Online Access:http://www.mdpi.com/2076-393X/4/4/46