A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity

A growing number of cargo-specific effector proteins are being identified that interact with both dynein and dynactin and form processive dynein-dynactin-effector complexes. Here the authors identify and characterize a conserved mechanism of interaction between dynein and unrelated effector proteins...

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Main Authors:	In-Gyun Lee, Mara A. Olenick, Malgorzata Boczkowska, Clara Franzini-Armstrong, Erika L. F. Holzbaur, Roberto Dominguez
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03412-8

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spelling	doaj-1906ae3d8b11421f880a7d0604e616ad2021-05-11T09:41:16ZengNature Publishing GroupNature Communications2041-17232018-03-019111210.1038/s41467-018-03412-8A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivityIn-Gyun Lee0Mara A. Olenick1Malgorzata Boczkowska2Clara Franzini-Armstrong3Erika L. F. Holzbaur4Roberto Dominguez5Department of Physiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Physiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Physiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Cell and Developmental Biology, University of PennsylvaniaDepartment of Physiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Physiology, Perelman School of Medicine, University of PennsylvaniaA growing number of cargo-specific effector proteins are being identified that interact with both dynein and dynactin and form processive dynein-dynactin-effector complexes. Here the authors identify and characterize a conserved mechanism of interaction between dynein and unrelated effector proteins.https://doi.org/10.1038/s41467-018-03412-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	In-Gyun Lee Mara A. Olenick Malgorzata Boczkowska Clara Franzini-Armstrong Erika L. F. Holzbaur Roberto Dominguez
spellingShingle	In-Gyun Lee Mara A. Olenick Malgorzata Boczkowska Clara Franzini-Armstrong Erika L. F. Holzbaur Roberto Dominguez A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity Nature Communications
author_facet	In-Gyun Lee Mara A. Olenick Malgorzata Boczkowska Clara Franzini-Armstrong Erika L. F. Holzbaur Roberto Dominguez
author_sort	In-Gyun Lee
title	A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity
title_short	A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity
title_full	A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity
title_fullStr	A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity
title_full_unstemmed	A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity
title_sort	conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-03-01
description	A growing number of cargo-specific effector proteins are being identified that interact with both dynein and dynactin and form processive dynein-dynactin-effector complexes. Here the authors identify and characterize a conserved mechanism of interaction between dynein and unrelated effector proteins.
url	https://doi.org/10.1038/s41467-018-03412-8
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A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity

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