Oxidative stress and the enzyme system of aldehyde catabolism in the muscle mitochondria of immobilized pubertal rats

• Main Authors: Amjad Hamdallah, V. V. Davydov, V. N. Shvets
• Format: Article
• Language: English
• Published: National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2014-12-01
• Series: Ukrainian Biochemical Journal
• Subjects: aldehyde dehydrogenase; aldehyde reductase; aldehydes; glutathione transferase; immobilization stress; oxidative stress; protein carbonyls; pubertal age; Schiff bases
• Online Access: http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Hamdallah_Davydov_6_14.pdf
• ISSN: 2409-4943; 2413-5003

The aim of the work is to find out peculiarities in manifestation of oxidative stress and to determine activity of enzymes, responsible for utilization of endogenous aldehydes in the mitochondrial fraction of the skeletal (femoral) muscle in pubertal rats during immobilization stress. Our study has shown that differently directed changes in the activity of mitochondrial aldehyde dehydrogenases and aldehyde reductases occur in the pubertal immobilized rats, that limits the catabolism effectiveness as regards carbonyl products of free radical oxidation in the muscle cells. Corroboration of the effect under consideration is an increased level of protein free radical oxidation products in the mitochondria of the skeletal muscle. On the basis of the obtained data the authors draw a conclusion about an increased sensitivity of the skeletal muscle to the oxidative stress impact due to modulation in the state of enzyme system, responsible for utilization of endogenous aldehydes in the mitochondria.