Current concepts in the pathogenesis of spondyloarthritis

• Main Authors: Nibha Jain, Arumugam Moorthy
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2020-01-01
• Series: Indian Journal of Rheumatology
• Subjects: interleukin 17; interleukin 23; pathogenesis; spondyloarthritis
• Online Access: http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=5;spage=6;epage=12;aulast=Jain

Pathogenesis of spondyloarthritis (SpA) is multifactorial and still not understood entirely. The role of genetics including human leukocyte antigen B27 has been investigated extensively, which along with genome-wide association studies has helped us understand and postulate various theories. Environmental factors including gut dysbiosis, mechanical stress, and transduction have been implicated in the pathogenesis. Recently, the interleukin (IL)-17/IL-23 pathway has been major focus due to it being therapeutic target. Herein, we reviewed various recent developments and current concepts in the pathogenesis of SpA.