Effect of 28-Day Exposure to Fenpropathrin on the Activities of Serum Alanine Transaminase and Liver Antioxidant Enzymes in Mice
Fenpropathrin (FEN) was administered intraperitoneally in doses of 2.38 mg/kg, 5.9 5mg/kg, or 11.9 mg/kg b.w. to mice for 28 consecutive days. FEN did not significantly affect the activity of alanine transaminase (ALT) in the sera. Superoxide dismutase and glutathione peroxidase activities were sign...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2015-03-01
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| Series: | Bulletin of the Veterinary Institute in Pulawy |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bvip-2015-0025 |
| Summary: | Fenpropathrin (FEN) was administered intraperitoneally in doses of 2.38 mg/kg, 5.9 5mg/kg, or 11.9 mg/kg b.w. to mice for 28 consecutive days. FEN did not significantly affect the activity of alanine transaminase (ALT) in the sera. Superoxide dismutase and glutathione peroxidase activities were significantly elevated in the liver after a 28-d exposure to moderate or highest doses of the pesticide. These results demonstrate that the 28-day exposure to FEN leads to an up-regulation of expression of antioxidant enzymes in response to an oxidative stress in mouse liver without causing a significant increase in ALT activity. |
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| ISSN: | 2300-3235 |