Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34+ Progenitors in Collagen Gels

Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34+ Progenitors in Collagen Gels

Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipi...

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Main Authors: Daniele Avitabile, Katrin Salchert, Carsten Werner, Maurizio C. Capogrossi, Maurizio Pesce
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/542810
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spelling doaj-18f82c225e574c6a90193ddf485ac5092020-11-24T23:29:21ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/542810542810Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34+ Progenitors in Collagen GelsDaniele Avitabile0Katrin Salchert1Carsten Werner2Maurizio C. Capogrossi3Maurizio Pesce4Laboratorio di Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino, 20138 Milano, ItalyLaboratorio di Patologia Vascolare, Istituto Dermopatico dell’Immacolata, 00166 Rome, ItalyLaboratorio di Patologia Vascolare, Istituto Dermopatico dell’Immacolata, 00166 Rome, ItalyInstitute of Biofunctional Polymer Material, Leibniz-Institüt für Polymerforschung, 01069 Dresden, GermanyLaboratorio di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino IRCCS, Via Parea 4, 20138 Milano, ItalyVarious reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34+ cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis.http://dx.doi.org/10.1155/2013/542810
collection DOAJ
language English
format Article
sources DOAJ
author Daniele Avitabile
Katrin Salchert
Carsten Werner
Maurizio C. Capogrossi
Maurizio Pesce
spellingShingle Daniele Avitabile
Katrin Salchert
Carsten Werner
Maurizio C. Capogrossi
Maurizio Pesce
Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34+ Progenitors in Collagen Gels
BioMed Research International
author_facet Daniele Avitabile
Katrin Salchert
Carsten Werner
Maurizio C. Capogrossi
Maurizio Pesce
author_sort Daniele Avitabile
title Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34+ Progenitors in Collagen Gels
title_short Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34+ Progenitors in Collagen Gels
title_full Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34+ Progenitors in Collagen Gels
title_fullStr Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34+ Progenitors in Collagen Gels
title_full_unstemmed Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34+ Progenitors in Collagen Gels
title_sort growth induction and low-oxygen apoptosis inhibition of human cd34+ progenitors in collagen gels
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2013-01-01
description Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34+ cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis.
url http://dx.doi.org/10.1155/2013/542810
work_keys_str_mv AT danieleavitabile growthinductionandlowoxygenapoptosisinhibitionofhumancd34progenitorsincollagengels
AT katrinsalchert growthinductionandlowoxygenapoptosisinhibitionofhumancd34progenitorsincollagengels
AT carstenwerner growthinductionandlowoxygenapoptosisinhibitionofhumancd34progenitorsincollagengels
AT maurizioccapogrossi growthinductionandlowoxygenapoptosisinhibitionofhumancd34progenitorsincollagengels
AT mauriziopesce growthinductionandlowoxygenapoptosisinhibitionofhumancd34progenitorsincollagengels
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