A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae

A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae

Mitochondria are asymmetrically inherited during cell division, a process that can affect cell fate and lifespan. Here the authors describe a mechanism for mitochondrial quality control in yeast that maintains a reservoir of high-functioning mitochondria in mother cells and preserves maternal reprod...

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Main Authors: Wolfgang M. Pernice, Jason D. Vevea, Liza A. Pon
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10595
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spelling doaj-18f7274f073c4f1c90ae646677a329e42021-05-11T11:01:33ZengNature Publishing GroupNature Communications2041-17232016-02-017111210.1038/ncomms10595A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiaeWolfgang M. Pernice0Jason D. Vevea1Liza A. Pon2Department of Pathology and Cell Biology, Columbia University, 630 West 168th Street, P&S 14-442, New York, New York 10032, USADepartment of Pathology and Cell Biology, Columbia University, 630 West 168th Street, P&S 14-442, New York, New York 10032, USADepartment of Pathology and Cell Biology, Columbia University, 630 West 168th Street, P&S 14-442, New York, New York 10032, USAMitochondria are asymmetrically inherited during cell division, a process that can affect cell fate and lifespan. Here the authors describe a mechanism for mitochondrial quality control in yeast that maintains a reservoir of high-functioning mitochondria in mother cells and preserves maternal reproductive capacity.https://doi.org/10.1038/ncomms10595
collection DOAJ
language English
format Article
sources DOAJ
author Wolfgang M. Pernice
Jason D. Vevea
Liza A. Pon
spellingShingle Wolfgang M. Pernice
Jason D. Vevea
Liza A. Pon
A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae
Nature Communications
author_facet Wolfgang M. Pernice
Jason D. Vevea
Liza A. Pon
author_sort Wolfgang M. Pernice
title A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae
title_short A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae
title_full A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae
title_fullStr A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae
title_full_unstemmed A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae
title_sort role for mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in saccharomyces cerevisiae
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-02-01
description Mitochondria are asymmetrically inherited during cell division, a process that can affect cell fate and lifespan. Here the authors describe a mechanism for mitochondrial quality control in yeast that maintains a reservoir of high-functioning mitochondria in mother cells and preserves maternal reproductive capacity.
url https://doi.org/10.1038/ncomms10595
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