A Greener, Efficient Approach to Michael Addition of Barbituric Acid to Nitroalkene in Aqueous Diethylamine Medium

A Greener, Efficient Approach to Michael Addition of Barbituric Acid to Nitroalkene in Aqueous Diethylamine Medium

An efficient method for the synthesis of a variety of pyrimidine derivatives 3a–t by reaction of barbituric acids 1a,b as Michael donor with nitroalkenes 2a–k as Michael acceptor using an aqueous medium and diethylamine is described. This 1,4-addition strategy offers several advantages, such as usin...

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Bibliographic Details
Main Authors:	Hany J. Al-Najjar, Assem Barakat, Abdullah M. Al-Majid, Yahia N. Mabkhot, Manuel Weber, Hazem A. Ghabbour, Hoong-Kun Fun
Format:	Article
Language:	English
Published:	MDPI AG 2014-01-01
Series:	Molecules
Subjects:	Michael reactions barbituric acid aqueous media green chemistry
Online Access:	http://www.mdpi.com/1420-3049/19/1/1150

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