Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling

Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling

Caspase-2 is constitutively expressed in neurons yet its physiological function is not known. Here, the authors report a role for Caspase-2 activity in synaptic plasticity via a reduction in dendritic spine density through cleavage of Rictor suggesting a mechanism to explain the impairments in cogni...

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Bibliographic Details
Main Authors: Zhi-Xiang Xu, Ji-Wei Tan, Haifei Xu, Cassandra J. Hill, Olga Ostrovskaya, Kirill A. Martemyanov, Baoji Xu
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11575-1

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