Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling

Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling

Caspase-2 is constitutively expressed in neurons yet its physiological function is not known. Here, the authors report a role for Caspase-2 activity in synaptic plasticity via a reduction in dendritic spine density through cleavage of Rictor suggesting a mechanism to explain the impairments in cogni...

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Main Authors: Zhi-Xiang Xu, Ji-Wei Tan, Haifei Xu, Cassandra J. Hill, Olga Ostrovskaya, Kirill A. Martemyanov, Baoji Xu
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11575-1
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spelling doaj-18f0a7d21924425ea758ad604fe5ea8d2021-05-11T12:17:36ZengNature Publishing GroupNature Communications2041-17232019-08-0110111310.1038/s41467-019-11575-1Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signalingZhi-Xiang Xu0Ji-Wei Tan1Haifei Xu2Cassandra J. Hill3Olga Ostrovskaya4Kirill A. Martemyanov5Baoji Xu6Department of Neuroscience, The Scripps Research Institute FloridaDepartment of Neuroscience, The Scripps Research Institute FloridaDepartment of Neuroscience, The Scripps Research Institute FloridaDepartment of Neuroscience, The Scripps Research Institute FloridaDepartment of Neuroscience, The Scripps Research Institute FloridaDepartment of Neuroscience, The Scripps Research Institute FloridaDepartment of Neuroscience, The Scripps Research Institute FloridaCaspase-2 is constitutively expressed in neurons yet its physiological function is not known. Here, the authors report a role for Caspase-2 activity in synaptic plasticity via a reduction in dendritic spine density through cleavage of Rictor suggesting a mechanism to explain the impairments in cognitive flexibility observed in Caspase-2 knockout mice.https://doi.org/10.1038/s41467-019-11575-1
collection DOAJ
language English
format Article
sources DOAJ
author Zhi-Xiang Xu
Ji-Wei Tan
Haifei Xu
Cassandra J. Hill
Olga Ostrovskaya
Kirill A. Martemyanov
Baoji Xu
spellingShingle Zhi-Xiang Xu
Ji-Wei Tan
Haifei Xu
Cassandra J. Hill
Olga Ostrovskaya
Kirill A. Martemyanov
Baoji Xu
Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
Nature Communications
author_facet Zhi-Xiang Xu
Ji-Wei Tan
Haifei Xu
Cassandra J. Hill
Olga Ostrovskaya
Kirill A. Martemyanov
Baoji Xu
author_sort Zhi-Xiang Xu
title Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
title_short Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
title_full Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
title_fullStr Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
title_full_unstemmed Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
title_sort caspase-2 promotes ampa receptor internalization and cognitive flexibility via mtorc2-akt-gsk3β signaling
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-08-01
description Caspase-2 is constitutively expressed in neurons yet its physiological function is not known. Here, the authors report a role for Caspase-2 activity in synaptic plasticity via a reduction in dendritic spine density through cleavage of Rictor suggesting a mechanism to explain the impairments in cognitive flexibility observed in Caspase-2 knockout mice.
url https://doi.org/10.1038/s41467-019-11575-1
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