The effect of DanHong injection combined with Clopidogrel hydrogen sulphate tablets on the serum inflammatory factors, platelet activation and vascular endothelium function

• Main Authors: Chen-Guang Zhang1, Xin-Ling Zhang2, Ying Zhang1
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-04-01
• Series: Journal of Hainan Medical University
• Subjects: Acute coronary syndrome in patient DanHong injection Clopidogrel hydrogen sulphate tablets Inflammatory factors Platelet activation Vascular endothelium function
• Online Access: http://www.hnykdxxb.com/PDF/201707/9.pdf

Objective: Treated the patients with acute coronary syndrome by the DanHong injection combined with Clopidogrel hydrogen sulphate tablets, and defined the effect of this combined treatment on the serum inflammatory factors, the level of platelet activation and the vascular endothelium function. Methods: Selected 102 ACS patients who were admitted in our hospital from December 2014 to April 2016 as the research subjects, and divided them into the control group and observation group according to the data sheet method, each group was composed of 51 cases. The control group was treated with conventional therapy and Clopidogrel hydrogen sulphate tablets, the observation was given DanHong injection additionally on the basis of control group. The treatment period was 2 months. Detected the change level of related indexes of all patients before and after treatment, which contained the serum inflammatory factors (IL-6, TNF-α, hs-CRP), the level of platelet activation (sCD40L, CD62p, GPIIb/IIa receptor compound), and the vascular endothelium function (NO, ET-1, and vWF). Results: It was showed that each index of this two groups was no statistical significant (P>0.05) before treatment. After treatment, the level of IL-6, TNF-α, hs-CRP, sCD40L, CD62p, GPIIb/IIa receptor compound, ET-1 and vWF were decreased dramatically compared with that before treatment, it was statistical significant difference (P<0.05); Moreover, these indexes in the observation group was lower than the control group, there was statistical significant difference between this two groups (P<0.05). The NO level of all patients was increased significantly after treatment (P<0.05), and the level in observation group was increased more obviously than the control group, the interlock difference was statistical significant (P<0.05). Conclusions: It was confirmed that the DanHong injection combined with Clopidogrel hydrogen sulphate tablets could ameliorate the level of serum inflammatory factors effectively, depress the blood platelet activation, and improve the vascular endothelium function to a great extent, it was worthy of clinic treatment.