Improvement of allograft kidney biopsy yield by using a handheld smartphone microscope as an on-site evaluation device

• Main Authors: Wichien Sirithanaphol, Natthida Incharoen, Ukrit Rompsaithong, Pakorn Kiatsopit, Supanut Lumbiganon, Jarin Chindaprasirt
• Format: Article
• Language: English
• Published: Elsevier 2021-06-01
• Series: Heliyon
• Subjects: Kidney transplantation; Kidney biopsy; Smart lens; Microscopy; Yield
• Online Access: http://www.sciencedirect.com/science/article/pii/S2405844021012925

Background: Smart lens is a magnifying device that turns the smartphone into a microscopic exploring instrument. It is a convenient and inexpensive tool as an on-site evaluation device for the kidney biopsy specimen. We demonstrate the benefit of using a handheld smartphone microscope compared to the standard procedure in allograft kidney specimens. Material and methods: This was a cohort study of allograft kidney biopsies performed between June 2015 and November 2017 in Srinagarind Hospital, Khon Kaen University, Thailand. The clinical utility of the “Chula smart lens” applied to the smartphone as an on-site evaluation device was studied. Clinical data, diagnostic quality, and complications were retrospectively reviewed and compared between the smart lens group and the standard group. Results: The study cohort consisted of 93 allograft kidney biopsies (standard:47, smart lens:46). The mean age was 40.6 (18–48) years, and 63 patients (67.7%) were male. By using the smart lens device, the number of obtained tissue cores was higher (3.5 vs 2.9, p = 0.019) and the inadequacy rate for diagnosis was significantly lower (7% vs 21.3%, p = 0.05). Conclusion: Using a handheld smartphone microscope as an on-site evaluation device resulted in more positive glomeruli and diagnostic yield compared to the standard procedure.