Definition of morphological changes of hepar, myocardium and stomach cells in rats after carbamazepin and thyotriazolin administration

Definition of morphological changes of hepar, myocardium and stomach cells in rats after carbamazepin and thyotriazolin administration

We investigated the histological changes in rats after new complex drug administration. Seventy male white rats were used for this experiment. During 90 days they received carbamazepin and thyotriazolin compound. Compound were administered orally via gavage. We observed damaging action of high dose...

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Bibliographic Details
Main Authors: Opryshko V.I., Skvyrska K.O., Mamchur V.I., Mazur I.A., Kucherenko L.I.
Format: Article
Language:Russian
Published: Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy 2012-01-01
Series:Морфологія
Subjects:
carbamazepin
thyotriazolin
hepar
myocardium
stomach
histological changes
Online Access:http://www.morphology.dp.ua/_pub/MORPHO-2012-06-03/12ovipkt.pdf
Description
Summary:We investigated the histological changes in rats after new complex drug administration. Seventy male white rats were used for this experiment. During 90 days they received carbamazepin and thyotriazolin compound. Compound were administered orally via gavage. We observed damaging action of high dose carbamazepin on hepar, myocardium and stomach. Our data suggest that thyotriazolin reduce toxic effect of carbamazepin on hepar, myocardium and stomach.
ISSN:1997-9665

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