Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations

Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations

The intrinsic inhomogeneity of polymer networks is masked by the usual ensemble-averaged measurements. Here the authors construct direct maps of crosslinks in an actin network by selective labeling the crosslinks with fluorescent markers and characterize the local elasticity and cross-correlation be...

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Main Authors: Lingxiang Jiang, Qingqiao Xie, Boyce Tsang, Steve Granick
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11313-7
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spelling doaj-18b6db71920a45baa619b2fedbacd0cc2021-05-11T12:12:34ZengNature Publishing GroupNature Communications2041-17232019-07-011011810.1038/s41467-019-11313-7Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuationsLingxiang Jiang0Qingqiao Xie1Boyce Tsang2Steve Granick3College of Chemistry and Materials Science, Jinan UniversityCollege of Chemistry and Materials Science, Jinan UniversityDepartment of Physics, University of IllinoisCenter for Soft and Living Matter, Institute for Basic Science (IBS)The intrinsic inhomogeneity of polymer networks is masked by the usual ensemble-averaged measurements. Here the authors construct direct maps of crosslinks in an actin network by selective labeling the crosslinks with fluorescent markers and characterize the local elasticity and cross-correlation between crosslinks.https://doi.org/10.1038/s41467-019-11313-7
collection DOAJ
language English
format Article
sources DOAJ
author Lingxiang Jiang
Qingqiao Xie
Boyce Tsang
Steve Granick
spellingShingle Lingxiang Jiang
Qingqiao Xie
Boyce Tsang
Steve Granick
Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations
Nature Communications
author_facet Lingxiang Jiang
Qingqiao Xie
Boyce Tsang
Steve Granick
author_sort Lingxiang Jiang
title Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations
title_short Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations
title_full Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations
title_fullStr Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations
title_full_unstemmed Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations
title_sort single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-07-01
description The intrinsic inhomogeneity of polymer networks is masked by the usual ensemble-averaged measurements. Here the authors construct direct maps of crosslinks in an actin network by selective labeling the crosslinks with fluorescent markers and characterize the local elasticity and cross-correlation between crosslinks.
url https://doi.org/10.1038/s41467-019-11313-7
work_keys_str_mv AT lingxiangjiang singlecrosslinkmicroscopyinabiopolymernetworkdissectslocalelasticityfrommolecularfluctuations
AT qingqiaoxie singlecrosslinkmicroscopyinabiopolymernetworkdissectslocalelasticityfrommolecularfluctuations
AT boycetsang singlecrosslinkmicroscopyinabiopolymernetworkdissectslocalelasticityfrommolecularfluctuations
AT stevegranick singlecrosslinkmicroscopyinabiopolymernetworkdissectslocalelasticityfrommolecularfluctuations
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