Editorial: Establishing Genetic Pleiotropy to Identify Common Pharmacological Agents for Common Diseases

Editorial: Establishing Genetic Pleiotropy to Identify Common Pharmacological Agents for Common Diseases

Bibliographic Details
Main Authors:	Tracy A. O’Mara, Jyotsna Batra, Dylan Glubb
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-09-01
Series:	Frontiers in Pharmacology
Subjects:	pleiotropy GWAS endometrial cancer CYP19A1 drug target drug repurposing
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2019.01038/full

Similar Items

Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies candidate susceptibility genes for breast and ovarian cancer
by: Siddhartha P. Kar, et al.
Published: (2021-07-01)

HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases
by: Daniel M. Jordan, et al.
Published: (2019-10-01)

Implications of pleiotropy: Challenges and opportunities for mining Big Data in Biomedicine
by: Can eYang, et al.
Published: (2015-06-01)

Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data
by: Ali Khosravi, et al.
Published: (2019-06-01)

Enhancing the Promise of Drug Repositioning through Genetics
by: Jayne-Louise E. Pritchard, et al.
Published: (2017-12-01)

Genetic variation in adaptability and pleiotropy in budding yeast
by: Elizabeth R Jerison, et al.
Published: (2017-08-01)

Deciphering pleiotropy: How complex genes regulate behavior
by: Ina Anreiter, et al.
Published: (2018-03-01)

Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation
by: Grant Kinsler, et al.
Published: (2020-12-01)

Investigating Pleiotropy Between Depression and Autoimmune Diseases Using the UK Biobank
by: Kylie P. Glanville, et al.
Published: (2021-06-01)

Polygenic risk and pleiotropy in neurodegenerative diseases
by: Eftychia Bellou, et al.
Published: (2020-08-01)

Joint GWAS Analysis: Comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases
by: Michael J. McGeachie, et al.
Published: (2014-12-01)

Statistical methods to detect pleiotropy in human complex traits
by: Sophie Hackinger, et al.
Published: (2017-01-01)

Analysis of Promoter-Associated Chromatin Interactions Reveals Biologically Relevant Candidate Target Genes at Endometrial Cancer Risk Loci
by: Tracy A. O’Mara, et al.
Published: (2019-09-01)

Inhibition of the Formation In Vitro of Putatively Carcinogenic Metabolites Derived from <i>S. haematobium</i> and <i>O. viverrini</i> by Combination of Drugs with Antioxidants
by: Maria João Gouveia, et al.
Published: (2019-10-01)

Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function
by: William R Reay, et al.
Published: (2021-03-01)

Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
by: William P. Bone, et al.
Published: (2021-02-01)

Bayesian methods for multivariate modeling of pleiotropic SNP associations and genetic risk prediction
by: Stephen W Hartley, et al.
Published: (2012-09-01)

Repurposing of Antimicrobial Agents for Cancer Therapy: What Do We Know?
by: Christina Pfab, et al.
Published: (2021-06-01)

Circadian and Geotactic Behaviors: Genetic Pleiotropy in Drosophila Melanogaster
by: Dale L Clayton
Published: (2016-06-01)

Systematic in silico Evaluation of Leishmania spp. Proteomes for Drug Discovery
by: Crhisllane Rafaele dos Santos Vasconcelos, et al.
Published: (2021-04-01)

“Hard” Drug Repurposing for Precision Oncology: The Missing Link?
by: Pan Pantziarka, et al.
Published: (2018-06-01)

Drug repositioning or target repositioning: A structural perspective of drug-target-indication relationship for available repurposed drugs
by: Daniele Parisi, et al.
Published: (2020-01-01)

The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs
by: Axelle Marchant, et al.
Published: (2019-08-01)

Exploring the Genetic Correlation Between Growth and Immunity Based on Summary Statistics of Genome-Wide Association Studies
by: Zhe Zhang, et al.
Published: (2018-09-01)

Molecular targets and system biology approaches for drug repurposing against SARS-CoV-2
by: Rahul Kunwar Singh, et al.
Published: (2020-11-01)

Exploring anti-malarial potential of FDA approved drugs: an in silico approach
by: Gayatri Ramakrishnan, et al.
Published: (2017-07-01)

Editorial: Computational and Experimental Approaches in Multi-target Pharmacology
by: Thomas J. Anastasio
Published: (2017-06-01)

Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics
by: Chani J. Hodonsky, et al.
Published: (2020-03-01)

Drug target ranking for glioblastoma multiforme
by: Radhika Saraf, et al.
Published: (2021-04-01)

Drug Repurposing Using Biological Networks
by: Francisco Javier Somolinos, et al.
Published: (2021-06-01)

High-Throughput Screening of Entamoeba Identifies Compounds Which Target Both Life Cycle Stages and Which Are Effective Against Metronidazole Resistant Parasites
by: Gretchen M. Ehrenkaufer, et al.
Published: (2018-08-01)

Mechanisms of Change: A Population-Based Perspective on the Roles of Modularity and Pleiotropy in Diversification
by: James J. Lewis, et al.
Published: (2020-08-01)

Comparison Study of Computational Prediction Tools for Drug-Target Binding Affinities
by: Maha Thafar, et al.
Published: (2019-11-01)

Quantitative Systems Pharmacological Analysis of Drugs of Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1
by: Fen Pei, et al.
Published: (2019-03-01)

Genetic association studies of Alzheimer disease using multi-phenotype tests and gene-based tests
by: Chung, Jaeyoon
Published: (2018)

Antagonistic pleiotropy and the evolution of extraordinary lifespans in eusocial organisms
by: Jan J. Kreider, et al.
Published: (2021-06-01)

High-throughput prediction and analysis of drug-protein interactions in the druggable human proteome
by: Wang, Chen
Published: (2018)

Repurposing Drugs for Acute Myeloid Leukemia: A Worthy Cause or a Futile Pursuit?
by: Anna V. Wojcicki, et al.
Published: (2020-02-01)

The Mu.Ta.Lig. Chemotheca: A Community-Populated Molecular Database for Multi-Target Ligands Identification and Compound-Repurposing
by: Francesco Ortuso, et al.
Published: (2018-04-01)

One For All? Hitting multiple Alzheimer’s Disease targets with one drug
by: Rebecca Ellen Hughes, et al.
Published: (2016-04-01)

Cannot write session to /tmp/vufind_sessions/sess_acjhm9b878fnnnnta14idmbhi0