CEACAM1 promotes melanoma metastasis and is involved in the regulation of the EMT associated gene network in melanoma cells

CEACAM1 promotes melanoma metastasis and is involved in the regulation of the EMT associated gene network in melanoma cells

Abstract We investigated the functional role of CEACAM1 in a spontaneous metastasis xenograft model of human melanoma in scid mice using BRAF wildtype MeWo cells with and without RNAi mediated knockdown of CEACAM1. Tumors from the xenograft model were subjected to whole genome expression analysis an...

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Bibliographic Details
Main Authors: Daniel Wicklein, Benjamin Otto, Anna Suling, Eva Elies, Georg Lüers, Tobias Lange, Susanne Feldhaus, Hanna Maar, Jennifer Schröder-Schwarz, Georg Brunner, Christoph Wagener, Udo Schumacher
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-30338-4

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