Titration of SF3B1 Activity Reveals Distinct Effects on the Transcriptome and Cell Physiology

Titration of SF3B1 Activity Reveals Distinct Effects on the Transcriptome and Cell Physiology

SF3B1 is a core component of the U2 spliceosome that is frequently mutated in cancer. We have previously shown that titrating the activity of SF3B1, using the inhibitor pladienolide B (PB), affects distinct steps of the heat shock response (HSR). Here, we identify other genes that are sensitive to d...

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Bibliographic Details
Main Authors: Karen S. Kim Guisbert, Isiah Mossiah, Eric Guisbert
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
SF3B1
heat shock response
HSR
alternative splicing
pladienolide B
nonsense-mediated decay
Online Access:https://www.mdpi.com/1422-0067/21/24/9641

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