p53 and Ceramide as Collaborators in the Stress Response

p53 and Ceramide as Collaborators in the Stress Response

The sphingolipid ceramide mediates various cellular processes in response to several extracellular stimuli. Some genotoxic stresses are able to induce p53-dependent ceramide accumulation leading to cell death. However, in other cases, in the absence of the tumor suppressor protein p53, apoptosis pro...

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Bibliographic Details
Main Authors: Ghassan Dbaibo, Hadile Kobeissy, Maria O. Esmerian, Rouba Hage-Sleiman
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:International Journal of Molecular Sciences
Subjects:
ceramide
p53
apoptosis
sphingolipids
mitochondria
signaling
Bcl2 family
caspase
Online Access:http://www.mdpi.com/1422-0067/14/3/4982

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