The Selective Rat Toxicant Norbormide Blocks KATP Channels in Smooth Muscle Cells But Not in Insulin-Secreting Cells

The Selective Rat Toxicant Norbormide Blocks KATP Channels in Smooth Muscle Cells But Not in Insulin-Secreting Cells

Norbormide is a toxicant selective for rats to which it induces a widespread vasoconstriction. In a recent paper, we hypothesized a role of ATP-sensitive potassium (KATP) channels in norbormide-induced vasoconstriction. The current study was undertaken to verify this hypothesis by comparing the effe...

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Bibliographic Details
Main Authors: Simona Saponara, Fabio Fusi, Ottavia Spiga, Alfonso Trezza, Brian Hopkins, Margaret A. Brimble, David Rennison, Sergio Bova
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
norbormide
glibenclamide
KATP channel
patch-clamp
molecular modeling
docking
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00598/full

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