Correlation Between Size of Renal Cell Carcinoma and Its Grade, Stage, and Histological Subtype

• Main Authors: Behrang Abadpour, Nasim Zamani, Reza Bashtar, Hamidreza Abdi, Mahmoud Parvin, Ali Tabibi
• Format: Article
• Language: English
• Published: Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences 2007-02-01
• Series: Urology Journal
• Subjects: kidney neoplasms; tumor size; pathologic grade; stage; renal; cell carcinoma
• Online Access: http://www.urologyjournal.org/index.php/uj/article/view/147/147
• ISSN: 1735-1308; 1735-546X

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Roman"; mso-bidi-font-family:"Times New Roman";} .MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:10.0pt; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt;} @page Section1 {size:612.0pt 792.0pt; margin:72.0pt 72.0pt 72.0pt 72.0pt; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> <!--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} </style> <![endif]--> <p class="MsoNormal"><strong>Introduction:</strong> The aim of this study was to determine the correlation between histological subtype, size, grade, and stage of the kidney tumors and to investigate whether a correlation exists between the size of the kidney tumor and its behavior.</p> <p class="MsoNormal"><strong>Materials and Methods: </strong>Between 1996 and 2004, we had 212 patients with radical or partial nephrectomy due to a kidney tumor at Shaheed Labbafinejad Medical Center. Their pathologic blocks were re-evaluated with consideration of their tumor size and pathologic features.</p> <p class="MsoNormal"><strong>Results: </strong>Of 212 pathologic blocks, 17 (8%) were benign and 195 (92%) were malignant masses including 179 renal cell carcinoma (RCC) tumors. Malignant tumors were slightly greater compared with the benign ones (<em>P</em> = .10). There was no significant relation between the size of tumor and the histological subtype. Significant relations between the size of the kidney tumor and the nuclear grade (<em>P </em>= .007), clinical symptoms (<em>P</em> = .02), and extracapsular extension (<em>P</em> < .001) were observed. In smaller RCC tumors (< 4 cm), extracapsular extension (stages T3 and T4) was rare (1 in 29).<span> </span>However, smaller RCC tumors were not significantly different from those larger than 4 cm regarding the nuclear grade, symptoms, and histological subtypes.</p> <strong><span style="font-size: 12pt; font-family: ">Conclusions</span></strong><span style="font-size: 12pt; font-family: ">: Tumor size is not an independent predictor for the histological subtype of the tumors; however, larger malignant tumors may have higher grades, higher stages, and clinical symptoms. </span>