Gel-Free 3D Tumoroids with Stem Cell Properties Modeling Drug Resistance to Cisplatin and Imatinib in Metastatic Colorectal Cancer

Gel-Free 3D Tumoroids with Stem Cell Properties Modeling Drug Resistance to Cisplatin and Imatinib in Metastatic Colorectal Cancer

Researchers have developed several three-dimensional (3D) culture systems, including spheroids, organoids, and tumoroids with increased properties of cancer stem cells (CSCs), also called cancer-initiating cells (CICs). Drug resistance is a crucial issue involving recurrence in cancer patients. Many...

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Bibliographic Details
Main Authors: Chiharu Sogawa, Takanori Eguchi, Yuri Namba, Yuka Okusha, Eriko Aoyama, Kazumi Ohyama, Kuniaki Okamoto
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
gel-free 3D culture
tumoroid
cisplatin resistance
imatinib (gleevec)
tyrosine kinase inhibitor (TKI)
spheroid
Online Access:https://www.mdpi.com/2073-4409/10/2/344

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