LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression.

LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression.

There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, we and others have found that COX-1, not COX-2, is responsible for vascula...

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Bibliographic Details
Main Authors: Nicholas S Kirkby, Anne K Zaiss, Paula Urquhart, Jing Jiao, Philip J Austin, Malak Al-Yamani, Martina H Lundberg, Louise S MacKenzie, Timothy D Warner, Anna Nicolaou, Harvey R Herschman, Jane A Mitchell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3711559?pdf=render

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