Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells

Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells

OmpR is a transcription factor activated in acid and osmotic responses of Gram-negative bacteria, leading to acidification of the bacterial cytoplasm. Here the authors use single cell pH imaging to define the role of OmpR-regulated genes in the acidification response to osmotic and acid stress of Sa...

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Main Authors: Smarajit Chakraborty, Ricksen S. Winardhi, Leslie K. Morgan, Jie Yan, Linda J. Kenney
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02030-0
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spelling doaj-189cfa10e5dc4b49a66243af61ebc8452021-05-11T07:35:37ZengNature Publishing GroupNature Communications2041-17232017-11-018111410.1038/s41467-017-02030-0Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cellsSmarajit Chakraborty0Ricksen S. Winardhi1Leslie K. Morgan2Jie Yan3Linda J. Kenney4Mechanobiology Institute, National University of SingaporeMechanobiology Institute, National University of SingaporeJesse Brown Veterans Affairs Medical CenterMechanobiology Institute, National University of SingaporeMechanobiology Institute, National University of SingaporeOmpR is a transcription factor activated in acid and osmotic responses of Gram-negative bacteria, leading to acidification of the bacterial cytoplasm. Here the authors use single cell pH imaging to define the role of OmpR-regulated genes in the acidification response to osmotic and acid stress of Salmonella and E. coli.https://doi.org/10.1038/s41467-017-02030-0
collection DOAJ
language English
format Article
sources DOAJ
author Smarajit Chakraborty
Ricksen S. Winardhi
Leslie K. Morgan
Jie Yan
Linda J. Kenney
spellingShingle Smarajit Chakraborty
Ricksen S. Winardhi
Leslie K. Morgan
Jie Yan
Linda J. Kenney
Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells
Nature Communications
author_facet Smarajit Chakraborty
Ricksen S. Winardhi
Leslie K. Morgan
Jie Yan
Linda J. Kenney
author_sort Smarajit Chakraborty
title Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells
title_short Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells
title_full Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells
title_fullStr Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells
title_full_unstemmed Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells
title_sort non-canonical activation of ompr drives acid and osmotic stress responses in single bacterial cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description OmpR is a transcription factor activated in acid and osmotic responses of Gram-negative bacteria, leading to acidification of the bacterial cytoplasm. Here the authors use single cell pH imaging to define the role of OmpR-regulated genes in the acidification response to osmotic and acid stress of Salmonella and E. coli.
url https://doi.org/10.1038/s41467-017-02030-0
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AT lesliekmorgan noncanonicalactivationofomprdrivesacidandosmoticstressresponsesinsinglebacterialcells
AT jieyan noncanonicalactivationofomprdrivesacidandosmoticstressresponsesinsinglebacterialcells
AT lindajkenney noncanonicalactivationofomprdrivesacidandosmoticstressresponsesinsinglebacterialcells
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