Increased Frequency of Peripheral B and T Cells Expressing Granulocyte Monocyte Colony-Stimulating Factor in Rheumatoid Arthritis Patients

Increased Frequency of Peripheral B and T Cells Expressing Granulocyte Monocyte Colony-Stimulating Factor in Rheumatoid Arthritis Patients

ObjectivesGranulocyte monocyte colony-stimulating factor (GM-CSF) is currently considered a crucial inflammatory mediator and a novel therapeutic target in rheumatoid arthritis (RA), despite the fact that its precise cellular sources remain uncertain. We studied the expression of GM-CSF in periphera...

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Bibliographic Details
Main Authors: Anastasia Makris, Sofia Adamidi, Christos Koutsianas, Christina Tsalapaki, Emilia Hadziyannis, Dimitrios Vassilopoulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
granulocyte monocyte colony-stimulating factor
methotrexate
tumor necrosis factor inhibitors
cytokines
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01967/full

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