REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway

Using several human and murine models, Zhang et al discover a role for the REG3A/REG3B proteins in acinar to ductal metaplasia (ADM), a precursor of pancreatic ductal adenocarcinoma (PDAC). They find that REG3B induces ADM through RAS-RAF-MEK-ERK signaling and identify EXTL3 as a REG3B receptor, pro...

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Main Authors:	Huairong Zhang, Andrea Liliam Gomez Corredor, Julia Messina-Pacheco, Qing Li, George Zogopoulos, Nancy Kaddour, Yifan Wang, Bing-yin Shi, Alex Gregorieff, Jun-li Liu, Zu-hua Gao
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-02193-z

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spelling	doaj-187a4a144b6748659950952e1f8ad2db2021-06-13T11:33:36ZengNature Publishing GroupCommunications Biology2399-36422021-06-014111310.1038/s42003-021-02193-zREG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathwayHuairong Zhang0Andrea Liliam Gomez Corredor1Julia Messina-Pacheco2Qing Li3George Zogopoulos4Nancy Kaddour5Yifan Wang6Bing-yin Shi7Alex Gregorieff8Jun-li Liu9Zu-hua Gao10Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pathology, McGill University and the Research Institute of McGill University Health CentreDepartment of Pathology, McGill University and the Research Institute of McGill University Health CentreHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center (MSKCC)Department of Surgery, McGill University and the Research Institute of McGill University Health CentreDepartment of Medicine, McGill University and the Research Institute of McGill University Health CentreDepartment of Surgery, McGill University and the Research Institute of McGill University Health CentreDepartment of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Pathology, McGill University and the Research Institute of McGill University Health CentreDepartment of Medicine, McGill University and the Research Institute of McGill University Health CentreDepartment of Pathology, McGill University and the Research Institute of McGill University Health CentreUsing several human and murine models, Zhang et al discover a role for the REG3A/REG3B proteins in acinar to ductal metaplasia (ADM), a precursor of pancreatic ductal adenocarcinoma (PDAC). They find that REG3B induces ADM through RAS-RAF-MEK-ERK signaling and identify EXTL3 as a REG3B receptor, providing new insights into PDAC development.https://doi.org/10.1038/s42003-021-02193-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Huairong Zhang Andrea Liliam Gomez Corredor Julia Messina-Pacheco Qing Li George Zogopoulos Nancy Kaddour Yifan Wang Bing-yin Shi Alex Gregorieff Jun-li Liu Zu-hua Gao
spellingShingle	Huairong Zhang Andrea Liliam Gomez Corredor Julia Messina-Pacheco Qing Li George Zogopoulos Nancy Kaddour Yifan Wang Bing-yin Shi Alex Gregorieff Jun-li Liu Zu-hua Gao REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway Communications Biology
author_facet	Huairong Zhang Andrea Liliam Gomez Corredor Julia Messina-Pacheco Qing Li George Zogopoulos Nancy Kaddour Yifan Wang Bing-yin Shi Alex Gregorieff Jun-li Liu Zu-hua Gao
author_sort	Huairong Zhang
title	REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway
title_short	REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway
title_full	REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway
title_fullStr	REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway
title_full_unstemmed	REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway
title_sort	reg3a/reg3b promotes acinar to ductal metaplasia through binding to extl3 and activating the ras-raf-mek-erk signaling pathway
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-06-01
description	Using several human and murine models, Zhang et al discover a role for the REG3A/REG3B proteins in acinar to ductal metaplasia (ADM), a precursor of pancreatic ductal adenocarcinoma (PDAC). They find that REG3B induces ADM through RAS-RAF-MEK-ERK signaling and identify EXTL3 as a REG3B receptor, providing new insights into PDAC development.
url	https://doi.org/10.1038/s42003-021-02193-z
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REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway

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