Disruption of Tfh:B Cell Interactions Prevents Antibody-Mediated Rejection in a Kidney Transplant Model in Rats: Impact of Calcineurin Inhibitor Dose

Disruption of Tfh:B Cell Interactions Prevents Antibody-Mediated Rejection in a Kidney Transplant Model in Rats: Impact of Calcineurin Inhibitor Dose

We aimed to investigate the mechanisms of humoral immune activation in ABMR using a MHC-mismatched rat kidney transplant model. We applied low dose cyclosporine A (loCNI) to allow donor-specific antibody (DSA) formation and rejection and high dose cyclosporine A (hiCNI) for non-rejection. DSA and le...

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Bibliographic Details
Main Authors: Louisa Steines, Helen Poth, Antonia Schuster, Kerstin Amann, Bernhard Banas, Tobias Bergler
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
antibody-mediated rejection
donor-specific antibodies
kidney transplantation
T follicular helper cells
B cell activation
calcineurin inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.657894/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.657894/full

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