Selected Fungal Natural Products with Antimicrobial Properties
Fungal natural products and their effects have been known to humankind for hundreds of years. For example, toxic ergot alkaloids produced by filamentous fungi growing on rye poisoned thousands of people and livestock throughout the Middle Ages. However, their later medicinal applications, followed b...
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doaj-1870678f16904ece93a6225ca365d0082020-11-24T21:02:03ZengMDPI AGMolecules1420-30492020-02-0125491110.3390/molecules25040911molecules25040911Selected Fungal Natural Products with Antimicrobial PropertiesDorota Jakubczyk0Francois Dussart1Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznań, PolandDepartment of Agriculture, Horticulture and Engineering Science, Scotland’s Rural College (SRUC), Edinburgh EH9 3JG, UKFungal natural products and their effects have been known to humankind for hundreds of years. For example, toxic ergot alkaloids produced by filamentous fungi growing on rye poisoned thousands of people and livestock throughout the Middle Ages. However, their later medicinal applications, followed by the discovery of the first class of antibiotics, penicillins and other drugs of fungal origin, such as peptidic natural products, terpenoids or polyketides, have altered the historically negative reputation of fungal “toxins”. The development of new antimicrobial drugs is currently a major global challenge, mainly due to antimicrobial resistance phenomena. Therefore, the structures, biosynthesis and antimicrobial activity of selected fungal natural products are described here.https://www.mdpi.com/1420-3049/25/4/911antimicrobial propertiesantimicrobial resistancebiosynthesisergot alkaloidsfungal metabolitesnatural productspeptidespolyketidesterpenoids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dorota Jakubczyk Francois Dussart |
spellingShingle |
Dorota Jakubczyk Francois Dussart Selected Fungal Natural Products with Antimicrobial Properties Molecules antimicrobial properties antimicrobial resistance biosynthesis ergot alkaloids fungal metabolites natural products peptides polyketides terpenoids |
author_facet |
Dorota Jakubczyk Francois Dussart |
author_sort |
Dorota Jakubczyk |
title |
Selected Fungal Natural Products with Antimicrobial Properties |
title_short |
Selected Fungal Natural Products with Antimicrobial Properties |
title_full |
Selected Fungal Natural Products with Antimicrobial Properties |
title_fullStr |
Selected Fungal Natural Products with Antimicrobial Properties |
title_full_unstemmed |
Selected Fungal Natural Products with Antimicrobial Properties |
title_sort |
selected fungal natural products with antimicrobial properties |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2020-02-01 |
description |
Fungal natural products and their effects have been known to humankind for hundreds of years. For example, toxic ergot alkaloids produced by filamentous fungi growing on rye poisoned thousands of people and livestock throughout the Middle Ages. However, their later medicinal applications, followed by the discovery of the first class of antibiotics, penicillins and other drugs of fungal origin, such as peptidic natural products, terpenoids or polyketides, have altered the historically negative reputation of fungal “toxins”. The development of new antimicrobial drugs is currently a major global challenge, mainly due to antimicrobial resistance phenomena. Therefore, the structures, biosynthesis and antimicrobial activity of selected fungal natural products are described here. |
topic |
antimicrobial properties antimicrobial resistance biosynthesis ergot alkaloids fungal metabolites natural products peptides polyketides terpenoids |
url |
https://www.mdpi.com/1420-3049/25/4/911 |
work_keys_str_mv |
AT dorotajakubczyk selectedfungalnaturalproductswithantimicrobialproperties AT francoisdussart selectedfungalnaturalproductswithantimicrobialproperties |
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1716776751016706048 |