Selected Fungal Natural Products with Antimicrobial Properties

Fungal natural products and their effects have been known to humankind for hundreds of years. For example, toxic ergot alkaloids produced by filamentous fungi growing on rye poisoned thousands of people and livestock throughout the Middle Ages. However, their later medicinal applications, followed b...

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Main Authors: Dorota Jakubczyk, Francois Dussart
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/25/4/911
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spelling doaj-1870678f16904ece93a6225ca365d0082020-11-24T21:02:03ZengMDPI AGMolecules1420-30492020-02-0125491110.3390/molecules25040911molecules25040911Selected Fungal Natural Products with Antimicrobial PropertiesDorota Jakubczyk0Francois Dussart1Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznań, PolandDepartment of Agriculture, Horticulture and Engineering Science, Scotland’s Rural College (SRUC), Edinburgh EH9 3JG, UKFungal natural products and their effects have been known to humankind for hundreds of years. For example, toxic ergot alkaloids produced by filamentous fungi growing on rye poisoned thousands of people and livestock throughout the Middle Ages. However, their later medicinal applications, followed by the discovery of the first class of antibiotics, penicillins and other drugs of fungal origin, such as peptidic natural products, terpenoids or polyketides, have altered the historically negative reputation of fungal “toxins”. The development of new antimicrobial drugs is currently a major global challenge, mainly due to antimicrobial resistance phenomena. Therefore, the structures, biosynthesis and antimicrobial activity of selected fungal natural products are described here.https://www.mdpi.com/1420-3049/25/4/911antimicrobial propertiesantimicrobial resistancebiosynthesisergot alkaloidsfungal metabolitesnatural productspeptidespolyketidesterpenoids
collection DOAJ
language English
format Article
sources DOAJ
author Dorota Jakubczyk
Francois Dussart
spellingShingle Dorota Jakubczyk
Francois Dussart
Selected Fungal Natural Products with Antimicrobial Properties
Molecules
antimicrobial properties
antimicrobial resistance
biosynthesis
ergot alkaloids
fungal metabolites
natural products
peptides
polyketides
terpenoids
author_facet Dorota Jakubczyk
Francois Dussart
author_sort Dorota Jakubczyk
title Selected Fungal Natural Products with Antimicrobial Properties
title_short Selected Fungal Natural Products with Antimicrobial Properties
title_full Selected Fungal Natural Products with Antimicrobial Properties
title_fullStr Selected Fungal Natural Products with Antimicrobial Properties
title_full_unstemmed Selected Fungal Natural Products with Antimicrobial Properties
title_sort selected fungal natural products with antimicrobial properties
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2020-02-01
description Fungal natural products and their effects have been known to humankind for hundreds of years. For example, toxic ergot alkaloids produced by filamentous fungi growing on rye poisoned thousands of people and livestock throughout the Middle Ages. However, their later medicinal applications, followed by the discovery of the first class of antibiotics, penicillins and other drugs of fungal origin, such as peptidic natural products, terpenoids or polyketides, have altered the historically negative reputation of fungal “toxins”. The development of new antimicrobial drugs is currently a major global challenge, mainly due to antimicrobial resistance phenomena. Therefore, the structures, biosynthesis and antimicrobial activity of selected fungal natural products are described here.
topic antimicrobial properties
antimicrobial resistance
biosynthesis
ergot alkaloids
fungal metabolites
natural products
peptides
polyketides
terpenoids
url https://www.mdpi.com/1420-3049/25/4/911
work_keys_str_mv AT dorotajakubczyk selectedfungalnaturalproductswithantimicrobialproperties
AT francoisdussart selectedfungalnaturalproductswithantimicrobialproperties
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