20-Hydroxy-3-Oxolupan-28-Oic Acid Attenuates Inflammatory Responses by Regulating PI3K–Akt and MAPKs Signaling Pathways in LPS-Stimulated RAW264.7 Macrophages

20-Hydroxy-3-Oxolupan-28-Oic Acid Attenuates Inflammatory Responses by Regulating PI3K–Akt and MAPKs Signaling Pathways in LPS-Stimulated RAW264.7 Macrophages

20-Hydroxy-3-oxolupan-28-oic acid (HOA), a lupane-type triterpene, was obtained from the leaves of <i>Mahonia bealei</i>, which is described in the Chinese Pharmacopeia as a remedy for inflammation and related diseases. The anti-inflammatory mechanisms of HOA, however, have not yet been...

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Bibliographic Details
Main Authors: Yufeng Cao, Fu Li, Yanyan Luo, Liang Zhang, Shuya Lu, Rui Xing, Bingjun Yan, Hongyin Zhang, Weicheng Hu
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Molecules
Subjects:
inflammation
nitric oxide
macrophage
NF-κB
lupane-type triterpene
Online Access:https://www.mdpi.com/1420-3049/24/3/386

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