Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents

Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents

Treatment of patients with triple-negative breast cancer (TNBC) is challenging due to the absence of well- defined molecular targets and the heterogeneity of such disease. In our endeavor to develop potent isatin-based anti-proliferative agents, we utilized the hybrid-pharmacophore approach to synth...

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Bibliographic Details
Main Authors: Wagdy M. Eldehna, Hadia Almahli, Ghada H. Al-Ansary, Hazem A. Ghabbour, Mohamed H. Aly, Omnia E. Ismael, Abdullah Al-Dhfyan, Hatem A. Abdel-Aziz
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Isatin
quinazoline
phthalazine
synthesis
triple-negative breast cancer
Online Access:http://dx.doi.org/10.1080/14756366.2017.1279155

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