A deficiency of apoptosis inducing factor (AIF) in Harlequin mouse heart mitochondria paradoxically reduces ROS generation during ischemia-reperfusion

A deficiency of apoptosis inducing factor (AIF) in Harlequin mouse heart mitochondria paradoxically reduces ROS generation during ischemia-reperfusion

Background and Aims: AIF (apoptosis inducing factor) is a flavin and NADH containing protein located within mitochondria required for optimal function of the respiratory chain. AIF may function as an antioxidant within mitochondria, yet when released from mitochondria it activates caspase-independ...

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Bibliographic Details
Main Authors: Qun eChen, Karol eSzczepanek, Ying eHu, Jeremy eThompson, Edward J. Lesnefsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Physiology
Subjects:
Apoptosis
Mitochondria
Poly(ADP-ribose) Polymerases
Reactive Oxygen Species
electron transport chain
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00271/full

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