A strain-variable bacteriocin in <it>Bacillus anthracis </it>and <it>Bacillus cereus </it>with repeated Cys-Xaa-Xaa motifs

• Main Author: Haft Daniel H
• Format: Article
• Language: English
• Published: BMC 2009-04-01
• Series: Biology Direct
• Online Access: http://www.biology-direct.com/content/4/1/15

<p>Abstract</p> <p/> <p>Bacteriocins are peptide antibiotics from ribosomally translated precursors, produced by bacteria often through extensive post-translational modification. Minimal sequence conservation, short gene lengths, and low complexity sequence can hinder bacteriocin identification, even during gene calling, so they are often discovered by proximity to accessory genes encoding maturation, immunity, and export functions. This work reports a new subfamily of putative thiazole-containing heterocyclic bacteriocins. It appears universal in all strains of <it>Bacillus anthracis </it>and <it>B. cereus</it>, but has gone unrecognized because it is always encoded far from its maturation protein operon. Patterns of insertions and deletions among twenty-four variants suggest a repeating functional unit of Cys-Xaa-Xaa.</p> <p>Reviewers</p> <p>This article was reviewed by Andrei Osterman and Lakshminarayan Iyer.</p>