Radiation, Immune Checkpoint Blockade and the Abscopal Effect: A Critical Review on Timing, Dose and Fractionation

Radiation, Immune Checkpoint Blockade and the Abscopal Effect: A Critical Review on Timing, Dose and Fractionation

The combination of radiation and immunotherapy is currently an exciting avenue of pre-clinical and clinical investigation. The synergy between these two treatment modalities has the potential to expand the role of radiation from a purely local therapy, to a role in advanced and metastatic disease. T...

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Bibliographic Details
Main Authors: Zachary S. Buchwald, Jacob Wynne, Tahseen H. Nasti, Simeng Zhu, Waleed F. Mourad, Weisi Yan, Seema Gupta, Samir N. Khleif, Mohammad K. Khan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Oncology
Subjects:
radiation
immunotherapy
checkpoint blockade
abscopal effect
PD-1
PD-L1
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00612/full

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