In Vitro-In Silico Tools for Streamlined Development of Acalabrutinib Amorphous Solid Dispersion Tablets

In Vitro-In Silico Tools for Streamlined Development of Acalabrutinib Amorphous Solid Dispersion Tablets

Amorphous solid dispersion (ASD) dosage forms can improve the oral bioavailability of poorly water-soluble drugs, enabling the commercialization of new chemical entities and improving the efficacy and patient compliance of existing drugs. However, the development of robust, high-performing ASD dosag...

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Bibliographic Details
Main Authors: Deanna M. Mudie, Aaron M. Stewart, Jesus A. Rosales, Molly S. Adam, Michael M. Morgen, David T. Vodak
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceutics
Subjects:
acalabrutinib
amorphous solid dispersion
bioavailability enhancement
acid reducing agent
proton pump inhibitor
kinase inhibitor
Online Access:https://www.mdpi.com/1999-4923/13/8/1257

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https://www.mdpi.com/1999-4923/13/8/1257

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