Delayed toxicity associated with soluble anthrax toxin receptor decoy-Ig fusion protein treatment.

Delayed toxicity associated with soluble anthrax toxin receptor decoy-Ig fusion protein treatment.

Soluble receptor decoy inhibitors, including receptor-immunogloubulin (Ig) fusion proteins, have shown promise as candidate anthrax toxin therapeutics. These agents act by binding to the receptor-interaction site on the protective antigen (PA) toxin subunit, thereby blocking toxin binding to cell su...

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Bibliographic Details
Main Authors: Diane Thomas, John Naughton, Christopher Cote, Susan Welkos, Marianne Manchester, John A T Young
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3325282?pdf=render

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