Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres

Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres

Differentiation of columnar epithelial cells involves a dramatic reorganization of the microtubules (MTs) and centrosomal components into an apico-basal array no longer anchored at the centrosome. Instead, the minus-ends of the MTs become anchored at apical non-centrosomal microtubule organizing cen...

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Bibliographic Details
Main Authors: Deborah A. Goldspink, Chris Rookyard, Benjamin J. Tyrrell, Jonathan Gadsby, James Perkins, Elizabeth K. Lund, Niels Galjart, Paul Thomas, Tom Wileman, Mette M. Mogensen
Format: Article
Language:English
Published: The Royal Society 2017-01-01
Series:Open Biology
Subjects:
microtubules
ninein
clip-170
iqgap1
rac1
non-centrosomal mtocs
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160274

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