Basal constriction during midbrain–hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase

Basal constriction during midbrain–hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase

Basal constriction occurs at the zebrafish midbrain–hindbrain boundary constriction (MHBC) and is likely a widespread morphogenetic mechanism. 3D reconstruction demonstrates that MHBC cells are wedge-shaped, and initially constrict basally, with subsequent apical expansion. wnt5b is expressed in the...

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Bibliographic Details
Main Authors: Jennifer H. Gutzman, Ellie Graeden, Isabel Brachmann, Sayumi Yamazoe, James K. Chen, Hazel Sive
Format: Article
Language:English
Published: The Company of Biologists 2018-11-01
Series:Biology Open
Subjects:
Basal constriction
Cell shape
Morphogenesis
Zebrafish
Wnt5b
Focal adhesion kinase
Midbrain–hindbrain boundary
Online Access:http://bio.biologists.org/content/7/11/bio034520

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