Antifungal activity of the esssential oil of Seseli rigidum Waldst. & Kit. (Apiaceae) on the growth of isolates of Candida albicans

• Main Authors: Marčetić Mirjana D., Božić Dragana D., Milenković Marina T., Kovačević Mirjana M., Kovačević Nada N.
• Format: Article
• Language: srp
• Published: Pharmaceutical Association of Serbia, Belgrade, Serbia 2019-01-01
• Series: Arhiv za farmaciju
• Subjects: antifungal activity; seseli rigidum; essential oil; candida albicans
• Online Access: https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2019/0004-19631902067X.pdf

The antimicrobial activity of the essential oils of root, aerial parts and fruit from two natural populations of Seseli rigidum was tested against 28 isolates of Candida albicans and one laboratory control strain of C. albicans ATCC 10259. Strains of C. albicans were isolated from oropharyngeal swabs, vaginal and/or cervical swabs, eye swabs, wound swabs, feces and urine. The investigated strains showed high level of resistance towards the activity of control antimycotic agent fluconazole and to a lower extent towards amphotericin B. The S. rigidum essential oils, in the concentrations of 50-200 mg/ml, inhibited the growth of investigated strains (28.6-46.4% of tested strains). The essential oils of root from both localities showed antifungal effect at the concentration 50 mg/ml. The dominant compound in the root essential oils was falcarinol (57.5% and 88.8%). The lower activity was obtained with the essential oil of aerial parts or fruit. The 100 mg/ml of essential oil of aerial parts showed significant effect on C. albicans strains. The essential oil of fruit from population from Brdjanska gorge exerted somehow higher effect. It was characterised by higher a-pinene and b-phellandrene content and lower amount of sabinene. The obtained results revealed the significant antifungal effects of S. rigidum root, aerial parts and fruit essential oils against resistant strains of C. albicans.