Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis.

Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis.

The BCL-2 family protein BAK is a key regulator of mitochondrial apoptosis. BAK activation first involves N-terminal conformational changes that lead to the transient exposure of the BAK BH3 domain that then inserts into a hydrophobic groove on another BAK molecule to form symmetric dimers. We showe...

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Bibliographic Details
Main Authors: Abul Azad, Joanna Fox, Sabrina Leverrier, Alan Storey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3506661?pdf=render

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