Preparation and Characterization of Coaxial Electrospinning rhBMP2-Loaded Nanofiber Membranes

Preparation and Characterization of Coaxial Electrospinning rhBMP2-Loaded Nanofiber Membranes

DEX and rhBMP2-loaded core-shell nanofiber membranes were synthesized by electrospinning method in one step. Zein/PLLA, Zein-DEX/PLLA, Zein/PLLA-rhBMP2, and Zein-DEX/PLLA-rhBMP2 were fabricated; and morphology, hydrophilicity, mechanics properties, in vitro drug release behavior, cell proliferation,...

Full description

Bibliographic Details
Main Authors: He Zhao, Yali Ma, Dahui Sun, Wendi Ma, Jihang Yao, Mei Zhang
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Journal of Nanomaterials
Online Access:http://dx.doi.org/10.1155/2019/8106985
id doaj-1827775071344de587e5a5149fccc6ec
record_format Article
spelling doaj-1827775071344de587e5a5149fccc6ec2020-11-25T01:32:43ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292019-01-01201910.1155/2019/81069858106985Preparation and Characterization of Coaxial Electrospinning rhBMP2-Loaded Nanofiber MembranesHe Zhao0Yali Ma1Dahui Sun2Wendi Ma3Jihang Yao4Mei Zhang5Alan G. MacDiarmid Laboratory, College of Chemistry, Jilin University, Changchun 130012, ChinaAlan G. MacDiarmid Laboratory, College of Chemistry, Jilin University, Changchun 130012, ChinaNorman Bethune First Hospital, Jilin University, Changchun 130021, ChinaAlan G. MacDiarmid Laboratory, College of Chemistry, Jilin University, Changchun 130012, ChinaNorman Bethune First Hospital, Jilin University, Changchun 130021, ChinaAlan G. MacDiarmid Laboratory, College of Chemistry, Jilin University, Changchun 130012, ChinaDEX and rhBMP2-loaded core-shell nanofiber membranes were synthesized by electrospinning method in one step. Zein/PLLA, Zein-DEX/PLLA, Zein/PLLA-rhBMP2, and Zein-DEX/PLLA-rhBMP2 were fabricated; and morphology, hydrophilicity, mechanics properties, in vitro drug release behavior, cell proliferation, and osteogenic differentiation were investigated. The results showed that the dual-release system containing rhBMP2 and DEX prepared by electrospinning had rough surface, constant drug release behavior, and could also significantly promote cell proliferation and osteogenic differentiation of RMSCs, indicating that the scaffolds we fabricated might be suitable for bone tissue engineering.http://dx.doi.org/10.1155/2019/8106985
collection DOAJ
language English
format Article
sources DOAJ
author He Zhao
Yali Ma
Dahui Sun
Wendi Ma
Jihang Yao
Mei Zhang
spellingShingle He Zhao
Yali Ma
Dahui Sun
Wendi Ma
Jihang Yao
Mei Zhang
Preparation and Characterization of Coaxial Electrospinning rhBMP2-Loaded Nanofiber Membranes
Journal of Nanomaterials
author_facet He Zhao
Yali Ma
Dahui Sun
Wendi Ma
Jihang Yao
Mei Zhang
author_sort He Zhao
title Preparation and Characterization of Coaxial Electrospinning rhBMP2-Loaded Nanofiber Membranes
title_short Preparation and Characterization of Coaxial Electrospinning rhBMP2-Loaded Nanofiber Membranes
title_full Preparation and Characterization of Coaxial Electrospinning rhBMP2-Loaded Nanofiber Membranes
title_fullStr Preparation and Characterization of Coaxial Electrospinning rhBMP2-Loaded Nanofiber Membranes
title_full_unstemmed Preparation and Characterization of Coaxial Electrospinning rhBMP2-Loaded Nanofiber Membranes
title_sort preparation and characterization of coaxial electrospinning rhbmp2-loaded nanofiber membranes
publisher Hindawi Limited
series Journal of Nanomaterials
issn 1687-4110
1687-4129
publishDate 2019-01-01
description DEX and rhBMP2-loaded core-shell nanofiber membranes were synthesized by electrospinning method in one step. Zein/PLLA, Zein-DEX/PLLA, Zein/PLLA-rhBMP2, and Zein-DEX/PLLA-rhBMP2 were fabricated; and morphology, hydrophilicity, mechanics properties, in vitro drug release behavior, cell proliferation, and osteogenic differentiation were investigated. The results showed that the dual-release system containing rhBMP2 and DEX prepared by electrospinning had rough surface, constant drug release behavior, and could also significantly promote cell proliferation and osteogenic differentiation of RMSCs, indicating that the scaffolds we fabricated might be suitable for bone tissue engineering.
url http://dx.doi.org/10.1155/2019/8106985
work_keys_str_mv AT hezhao preparationandcharacterizationofcoaxialelectrospinningrhbmp2loadednanofibermembranes
AT yalima preparationandcharacterizationofcoaxialelectrospinningrhbmp2loadednanofibermembranes
AT dahuisun preparationandcharacterizationofcoaxialelectrospinningrhbmp2loadednanofibermembranes
AT wendima preparationandcharacterizationofcoaxialelectrospinningrhbmp2loadednanofibermembranes
AT jihangyao preparationandcharacterizationofcoaxialelectrospinningrhbmp2loadednanofibermembranes
AT meizhang preparationandcharacterizationofcoaxialelectrospinningrhbmp2loadednanofibermembranes
_version_ 1725080282988544000

Similar Items