Targeting claudin‐overexpressing thyroid and lung cancer by modified Clostridium perfringens enterotoxin

Targeting claudin‐overexpressing thyroid and lung cancer by modified Clostridium perfringens enterotoxin

Clostridium perfringens enterotoxin (CPE) can be used to eliminate carcinoma cells that overexpress on their cell surface CPE receptors – a subset of claudins (e.g., Cldn3 and Cldn4). However, CPE cannot target tumors expressing solely CPE‐insensitive claudins (such as Cldn1 and Cldn5). To overcome...

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Bibliographic Details
Main Authors: Anna Piontek, Miriam Eichner, Denise Zwanziger, Laura‐Sophie Beier, Jonas Protze, Wolfgang Walther, Sarah Theurer, Kurt Werner Schmid, Dagmar Führer‐Sakel, Jörg Piontek, Gerd Krause
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Molecular Oncology
Subjects:
claudins
Clostridium perfringens enterotoxin
directed mutagenesis
lung cancer
necrosis
thyroid cancer
Online Access:https://doi.org/10.1002/1878-0261.12615

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