Molecular-Biological Methods of Quality Control of Biological Active Substances Produced by Recombinant DNA Technology

Molecular-Biological Methods of Quality Control of Biological Active Substances Produced by Recombinant DNA Technology

Biotechnological products manufactured by recombinant DNA technology are widely used nowadays. According to the national and international requirements the amount of residual host cell DNA in such products should not exceed 10 ng per dose. However, for products intended for frequent or long-term...

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Bibliographic Details
Main Authors:	E. D. Mytsa, N. V. Chertova, E. V. Elbert, A. S. Sukhno, R. A. Volkova, V. A. Merkulov
Format:	Article
Language:	Russian
Published:	Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2018-06-01
Series:	Биопрепараты: Профилактика, диагностика, лечение
Subjects:	biotechnological products residual host cell dna recombinant proteins molecular-biological methods of quality control polymerase chain reaction (pcr) molecular hybridization method threshold system method based on the use of a fluorescent reagent
Online Access:	https://www.biopreparations.ru/jour/article/view/133

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