Verruciform Xanthoma of the Ventral Surface of the Tongue: A Rare Case Report and Literature Review

• Main Authors: Saedeh Atarbashi Moghadam, Ali Lotfi, Farnoush Kabiri, Soran Sijanivandi
• Format: Article
• Language: English
• Published: Mashhad University of Medical Sciences 2021-01-01
• Series: Iranian Journal of Otorhinolaryngology
• Subjects: benign; oral cavity; tongue; verruciform xanthoma
• Online Access: https://ijorl.mums.ac.ir/article_17229_5ccc5ac55d02ecc365df6c9c0094accf.pdf
• ISSN: 2251-7251; 2251-726X

Introduction: Verruciform xanthoma (VX) is an uncommon benign lesion with the subepithelial accumulation of foamy histiocytes and superficial papillary proliferations with a bright orange hue. This lesion exhibits an oral region predilection.Its clinical differential diagnosis includes verrucous leukoplakia, verrucous carcinoma, squamous papilloma, verruca vulgaris, condyloma accuminatum, squamous cell carcinoma, and fibroepithelial polyp.   Case Report: This report presents a case of VX of the ventral surface of the tongue afflicting a 33-year-old otherwise healthy male. Conclusion: This case report can be valuable as a consequence of VX rarity and the similarity of its clinical features to papillary lesions. A biopsy is required for its definite diagnosis particularly when it occurs at sites with a high-risk of squamous cell carcinoma development, such as the lateral border and ventral surface of the tongue.