Dynamic Modeling of Streptococcus pneumoniae Competence Provides Regulatory Mechanistic Insights Into Its Tight Temporal Regulation

Dynamic Modeling of Streptococcus pneumoniae Competence Provides Regulatory Mechanistic Insights Into Its Tight Temporal Regulation

In the human pathogen Streptococcus pneumoniae, the gene regulatory circuit leading to the transient state of competence for natural transformation is based on production of an auto-inducer that activates a positive feedback loop. About 100 genes are activated in two successive waves linked by a cen...

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Bibliographic Details
Main Authors: Mathias Weyder, Marc Prudhomme, Mathieu Bergé, Patrice Polard, Gwennaele Fichant
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
bacterial competence
negative and positive feedback loops
dynamic modeling
ordinary differential equations
transcriptional network
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01637/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01637/full

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