A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870

Protein kinase inhibitors frequently have interesting effects that cannot be fully ascribed to the intended target kinase(s) but identifying additional targets that might explain the effects is not straightforward. By comparing two different inhibitors of the Rsk (p90 ribosomal S6 kinase) kinases,...

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Bibliographic Details
Main Authors: Alexander J. Edgar, Matthias Trost, Colin Watts, Rossana Zaru
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2014-01-01
Series:Bioscience Reports
Subjects:
Online Access:http://www.bioscirep.org/bsr/034/e091/bsr034e091.htm