Design of a Type-1 Diabetes Vaccine Candidate Using Edible Plants Expressing a Major Autoantigen

Design of a Type-1 Diabetes Vaccine Candidate Using Edible Plants Expressing a Major Autoantigen

Type-1 diabetes (T1D) is a metabolic disease involving the autoimmune destruction of insulin-producing pancreatic beta cells. It is often diagnosed by the detection of autoantibodies, typically those recognizing insulin itself or the 65-kDa isoform of glutamic acid decarboxylase (GAD65). Oral insuli...

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Bibliographic Details
Main Authors: Edoardo Bertini, Matilde Merlin, Elisa Gecchele, Andrea Puggia, Annalisa Brozzetti, Mauro Commisso, Alberto Falorni, Vittorio Bini, Victor Klymyuk, Mario Pezzotti, Linda Avesani
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Plant Science
Subjects:
oral tolerance
autoimmune diabetes
immunotherapy
transient expression
red beet
molecular farming
Online Access:http://journal.frontiersin.org/article/10.3389/fpls.2018.00572/full

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