Pathway engineering in yeast for synthesizing the complex polyketide bikaverin
Bikaverin is a fungal-derived tetracyclic polyketide with antibiotic, antifungal and anticancer properties. Here, the authors employ various pathway engineering strategies to achieve high level production of bikaverin in baker’s yeast.
Bibliographic Details
| Main Authors: |
Meng Zhao,
Yu Zhao,
Mingdong Yao,
Hala Iqbal,
Qi Hu,
Hong Liu,
Bin Qiao,
Chun Li,
Christine A. S. Skovbjerg,
Jens Christian Nielsen,
Jens Nielsen,
Rasmus J. N. Frandsen,
Yingjin Yuan,
Jef D. Boeke |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-19984-3
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