The effects of substance P and acetylcholine on human tenocyte proliferation converge mechanistically via TGF-β1.

The effects of substance P and acetylcholine on human tenocyte proliferation converge mechanistically via TGF-β1.

Previous in vitro studies on human tendon cells (tenocytes) have demonstrated that the exogenous administration of substance P (SP) and acetylcholine (ACh) independently result in tenocyte proliferation, which is a prominent feature of tendinosis. Interestingly, the possible link between SP and ACh...

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Bibliographic Details
Main Authors: Gloria Fong, Ludvig J Backman, Håkan Alfredson, Alex Scott, Patrik Danielson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5354451?pdf=render

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