Significance of differential expression of thymidylate synthase in normal and primary tumor tissues from patients with colorectal cancer

Significance of differential expression of thymidylate synthase in normal and primary tumor tissues from patients with colorectal cancer

<p>Abstract</p> <p>The role of thymidylate synthase (TS) is essential as a key rate-limiting enzyme in DNA synthesis. It is the primary target of fluorouracil and its derivates in colorectal cancer. In this study, TS mRNA expression was examined in primary tumor and normal tissues...

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Main Authors: Hua Yawei, Wei Bing, Guo Hongqiang, Jia Yanzhao, Xia Qingxin, Liu Yanyan, Yang Shujun
Format: Article
Language:English
Published: BMC 2011-08-01
Series:Journal of Hematology & Oncology
Online Access:http://www.jhoonline.org/content/4/1/33
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spelling doaj-17e61a45e8964f6fa8c3b263bbdf49032020-11-24T21:46:03ZengBMCJournal of Hematology & Oncology1756-87222011-08-01413310.1186/1756-8722-4-33Significance of differential expression of thymidylate synthase in normal and primary tumor tissues from patients with colorectal cancerHua YaweiWei BingGuo HongqiangJia YanzhaoXia QingxinLiu YanyanYang Shujun<p>Abstract</p> <p>The role of thymidylate synthase (TS) is essential as a key rate-limiting enzyme in DNA synthesis. It is the primary target of fluorouracil and its derivates in colorectal cancer. In this study, TS mRNA expression was examined in primary tumor and normal tissues from 76 patients with high- risk stage II/III colorectal cancer by laser capture microdissection and polymerase chain reaction. Thirty (39.47%) patients were found to have higher TS expression in primary tumors with earlier stage (P = 0.018), lower histological grades (P = 0.001) and high frequency microsatellite instability (P = 0.000). Multivariate analysis showed that microsatellite instability, histological grade and number of lymph nodes examined are independent prognostic markers.</p> http://www.jhoonline.org/content/4/1/33
collection DOAJ
language English
format Article
sources DOAJ
author Hua Yawei
Wei Bing
Guo Hongqiang
Jia Yanzhao
Xia Qingxin
Liu Yanyan
Yang Shujun
spellingShingle Hua Yawei
Wei Bing
Guo Hongqiang
Jia Yanzhao
Xia Qingxin
Liu Yanyan
Yang Shujun
Significance of differential expression of thymidylate synthase in normal and primary tumor tissues from patients with colorectal cancer
Journal of Hematology & Oncology
author_facet Hua Yawei
Wei Bing
Guo Hongqiang
Jia Yanzhao
Xia Qingxin
Liu Yanyan
Yang Shujun
author_sort Hua Yawei
title Significance of differential expression of thymidylate synthase in normal and primary tumor tissues from patients with colorectal cancer
title_short Significance of differential expression of thymidylate synthase in normal and primary tumor tissues from patients with colorectal cancer
title_full Significance of differential expression of thymidylate synthase in normal and primary tumor tissues from patients with colorectal cancer
title_fullStr Significance of differential expression of thymidylate synthase in normal and primary tumor tissues from patients with colorectal cancer
title_full_unstemmed Significance of differential expression of thymidylate synthase in normal and primary tumor tissues from patients with colorectal cancer
title_sort significance of differential expression of thymidylate synthase in normal and primary tumor tissues from patients with colorectal cancer
publisher BMC
series Journal of Hematology & Oncology
issn 1756-8722
publishDate 2011-08-01
description <p>Abstract</p> <p>The role of thymidylate synthase (TS) is essential as a key rate-limiting enzyme in DNA synthesis. It is the primary target of fluorouracil and its derivates in colorectal cancer. In this study, TS mRNA expression was examined in primary tumor and normal tissues from 76 patients with high- risk stage II/III colorectal cancer by laser capture microdissection and polymerase chain reaction. Thirty (39.47%) patients were found to have higher TS expression in primary tumors with earlier stage (P = 0.018), lower histological grades (P = 0.001) and high frequency microsatellite instability (P = 0.000). Multivariate analysis showed that microsatellite instability, histological grade and number of lymph nodes examined are independent prognostic markers.</p>
url http://www.jhoonline.org/content/4/1/33
work_keys_str_mv AT huayawei significanceofdifferentialexpressionofthymidylatesynthaseinnormalandprimarytumortissuesfrompatientswithcolorectalcancer
AT weibing significanceofdifferentialexpressionofthymidylatesynthaseinnormalandprimarytumortissuesfrompatientswithcolorectalcancer
AT guohongqiang significanceofdifferentialexpressionofthymidylatesynthaseinnormalandprimarytumortissuesfrompatientswithcolorectalcancer
AT jiayanzhao significanceofdifferentialexpressionofthymidylatesynthaseinnormalandprimarytumortissuesfrompatientswithcolorectalcancer
AT xiaqingxin significanceofdifferentialexpressionofthymidylatesynthaseinnormalandprimarytumortissuesfrompatientswithcolorectalcancer
AT liuyanyan significanceofdifferentialexpressionofthymidylatesynthaseinnormalandprimarytumortissuesfrompatientswithcolorectalcancer
AT yangshujun significanceofdifferentialexpressionofthymidylatesynthaseinnormalandprimarytumortissuesfrompatientswithcolorectalcancer
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